منابع مشابه
The role of the entero-insular axis in insulin secretion.
The concept of an entero-insular axis has its origins in the 19th Century, after the observation that greater amounts of glucose could be given orally rather than intravenously without producing glycosuria. However, convincing evidence that the gut is able to modify the insulin response to an oral glucose load was produced by two groups of investigators in the 1960s, who showed that oral glucos...
متن کاملEffect of catch-up growth after food restriction on the entero-insular axis in rats
BACKGROUND Catch-up growth after food restriction (CUGFR) is characterized by a significant change in food intake which could theoretically lead to the change in glucagon-like peptide-1 (GLP-1) secretion that consequently results in altered functions of pancreatic islets. METHODS Experimental rats were divided into two groups. Rats in CUGFR group were put on food-restriction for 4 weeks, and ...
متن کاملGlucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice.
Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP) receptor gene (GIPR) were generated to determine the role of GIP as a mediator of signals from the gut to pancreatic beta cells. GIPR-/- mice have higher blood glucose levels with impaired initial insulin response after oral glucose load. Although blood glucose levels after meal ingestion are not increased by high-fat die...
متن کاملThe effect of energy source and feeding level on the hormones of the entero-insular axis and plasma glucose in the growing pig.
The aim of the experiment was to test the theory that accustoming pigs to a high-fat diet causes exaggerated gastric inhibitory polypeptide (GIP) secretion in response to a high-fat meal, and to determine whether hypersecretion of GIP could be related to an increase in the GIP content of the small intestine. Twenty-four pigs were fed one of three dietary regimens for 11 weeks: a high-carbohydra...
متن کاملQuantifying Insulin Sensitivity and Entero-Insular Responsiveness to Hyper- and Hypoglycemia in Ferrets
Ferrets are an important emerging model of cystic fibrosis related diabetes. However, there is little documented experience in the use of advanced techniques to quantify aspects of diabetes pathophysiology in the ferret. Glycemic clamps are the gold standard technique to assess both insulin sensitivity and insulin secretion in humans and animal models of diabetes. We therefore sought to develop...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1998
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250051070